|
|
tetrahydrobiopterin + NADP+ <=> biopterin + NADPH + H+
|
1.5.1.33
pteridine reductase
|
–
|
K
|
|
BRENDA:
BR43855
KEGG:
R01812
MetaCyc:
1.1.1.253-RXN
SABIO-RK:
1898
|
|
|
|
tetrahydrobiopterin + NADP+ <=> 6-pyruvoyltetrahydropterin + NADPH + H+
|
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
|
–
|
K
|
|
BRENDA:
BR50007
KEGG:
R08208
MetaCyc:
RXN-8853
|
|
|
|
tetrahydrobiopterin + NADP+ <=> (6R)-L-erythro-6,7-dihydrobiopterin + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
|
–
–
–
|
K
|
|
BRENDA:
BS319540;
BS388536
KEGG:
R01794;
R11765
MetaCyc:
RXN-14245
SABIO-RK:
1883;
7757
|
|
|
|
tetrahydrobiopterin + NAD+ <=> (6R)-L-erythro-6,7-dihydrobiopterin + NADH + H+
|
1.5.1.34
6,7-dihydropteridine reductase
|
–
|
K
|
|
BRENDA:
BS319540-a;
BS402604
KEGG:
R01793
MetaCyc:
RXN-14245_WOP
SABIO-RK:
1882
|
|
|
|
tyramine + tetrahydrobiopterin + O2 <=> dopamine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
M
|
|
BRENDA:
BS417733
MetaCyc:
RXN-9978
|
|
|
|
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH + H+ <=> tetrahydrobiopterin + NADP+
|
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
|
–
|
K
|
|
BRENDA:
BS187320
KEGG:
R01813
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
|
K
|
|
BRENDA:
BS288214
KEGG:
R01795
SABIO-RK:
1884
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydrobiopterin + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
K
|
|
BRENDA:
BS370244
KEGG:
R01815
SABIO-RK:
1901
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
K
|
|
BRENDA:
BS377086
KEGG:
R07212
SABIO-RK:
7156
|
|
|
|
1''-hydroxy-2''-oxopropyltetrahydropterin + NADPH <=> tetrahydrobiopterin + NADP+
|
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
1.1.1.21
aldose reductase
|
–
–
|
K
|
|
BRENDA:
BS383524
KEGG:
R11764
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
K
|
|
BRENDA:
BS386541
KEGG:
R07211
SABIO-RK:
8496
|
|
|
|
L-tryptophan + tetrahydrobiopterin + O2 <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
|
K
|
|
BRENDA:
BS386547
KEGG:
R07213
SABIO-RK:
8593
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-m-Tyr + 4a-hydroxytetrahydrobiopterin
|
1.14.16.7
phenylalanine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS424873
KEGG:
R10729
|
|
|
|
tetrahydrobiopterin + L-tryptophan + O2 <=> 5-hydroxy-L-tryptophan + dihydrobiopterin + H2O
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
K
|
|
KEGG:
R01814
SABIO-RK:
1900
|
|
|
|
tetrahydrobiopterin + NADP+ <=> (6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8854
|
|
|
|
UDP-glucose + tetrahydrobiopterin <=> (6R)-tetrahydrobiopterin-beta-D-glucoside + UDP + H+
|
2.4.1
|
–
|
|
|
MetaCyc:
RXN490-3608
|
|
|
|
L-tryptophan + tetrahydrobiopterin + O2 <=> 5-hydroxy-L-tryptophan
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS389069
|
|
|
|
S-carboxymethyl-L-cysteine + tetrahydrobiopterin + O2 <=> S-carboxymethyl-L-cysteine_S-oxide + dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS377746
|
|
|
|
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2 <=> 1-hydroxypyrenedecyl-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS395274
|
|
|
|
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2 <=> 1-alkyl-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS442130
|
|
|
|
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2 <=> 1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS370243
|
|
|
|
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2 <=> 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS427266
|
|
|
|
S-ethyl-L-cysteine + tetrahydrobiopterin + O2 <=> (S)-ethyl-L-cysteine_S-oxide + dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS403138
|
|
|
|
1-O-alkyl-sn-glycerol_3-phosphate + tetrahydrobiopterin + O2 <=> 1-O-(1-hydroxyalkyl)-sn-glycerol_3-phosphate + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS427267
|
|
|
|
prodigiosin + tetrahydrobiopterin + O2 <=> cycloprodigiosin + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS442515
|
|
|
|
anthranilate + tetrahydrobiopterin + O2 <=> 3-Hydroxyanthranilate + dihydrobiopterin + H2O
|
1.14.16.3
anthranilate 3-monooxygenase
|
–
|
|
|
BRENDA:
BR40404
|
|
|
|
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + tetrahydrobiopterin + O2 <=> glycerophosphocholine + an_n-alkanal + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS427265
|
|
|
|
lyso-alkyl-glycerol_phospholipid + tetrahydrobiopterin + O2 <=> 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS427477
|
|
|
|
S-methyl-L-cysteine + tetrahydrobiopterin + O2 <=> S-methyl-L-cysteine_S-oxide + dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS377753
|
|
|
|
1-palmitoyl-sn-glycerol + tetrahydrobiopterin + O2 <=> 1-O-(1-hydroxy-hexadecyl)-sn-glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS451344
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + L-threo-7,8-dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS370246
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + DL-m-Tyr + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS428743
|
|
|
|
L-tryptophan + tetrahydrobiopterin <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS417195
|
|
|
|
RS-3-hexadecyloxypropane-1,2-diol + tetrahydrobiopterin + O2 <=> hexadecanal + glycerol + dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS288110
|
|
|
|
alkylglycerol + tetrahydrobiopterin + O2 <=> glycerol + octadecanal + 6,7[8H]-dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS416526
|
|
|
|
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2 <=> glycerol + pyrenedecanal + 6,7[8H]-dihydrobiopterin + H2O
|
1.14.16.5
alkylglycerol monooxygenase
|
–
|
|
|
BRENDA:
BS416027
|
|
|
|
2 L-arginine + 2 tetrahydrobiopterin + 2 O2 <=> 2 Nomega-hydroxy-L-arginine + 2 biopterin + 2 H2O
|
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
|
|
|
BRENDA:
BS438665
|
|
|
|
2 L-arginine + 3 tetrahydrobiopterin + 4 O2 <=> 2 L-citrulline + 2 NO + 3 biopterin + 4 H2O
|
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
|
|
|
BRENDA:
BS438666
|
|
|
|
2 Nomega-hydroxy-L-arginine + tetrahydrobiopterin + 2 O2 <=> 2 L-citrulline + 2 NO + biopterin + 2 H2O
|
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
|
|
|
BRENDA:
BS438668
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydro-L-biopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS405668
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288194
|
|
|
|
dihydropteridine + NADH <=> tetrahydrobiopterin + NAD+
|
1.5.1.34
6,7-dihydropteridine reductase
|
–
|
|
|
BRENDA:
BS370829
|
|
|
|
1''-hydroxy-2''-oxopropyltetrahydropterin + NADP+ <=> tetrahydrobiopterin + NADPH
|
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
|
–
|
|
|
BRENDA:
BS187319
|
|
|
|
2 biopterin + 3 NADPH + 3 H+ <=> dihydrobiopterin + tetrahydrobiopterin + 3 NADP+
|
1.5.1.33
pteridine reductase
|
–
|
|
|
BRENDA:
BS394792
|
|
|
|
sepiapterin + NADPH + H+ <=> tetrahydrobiopterin + NADP+
|
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
1.1.1.325
sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
|
–
–
|
|
|
BRENDA:
BS438462
|
|